Drug interactions
Carvedilol + Venlafaxine
Severity: Minor
Carvedilol and Venlafaxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine is a weak CYP2D6 inhibitor and may slightly raise carvedilol exposure. Venlafaxine can also raise blood pressure, which may partly counter the effect of carvedilol.
What this interaction means in plain words
Carvedilol and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Venlafaxine belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP2D6 by venlafaxine may reduce carvedilol metabolism.
What to do
Monitor heart rate and blood pressure when venlafaxine is started or the dose changed, and adjust the carvedilol dose according to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Carvedilol with Venlafaxine?
MediHelp rates the interaction as minor. Carvedilol and Venlafaxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Venlafaxine is a weak CYP2D6 inhibitor and may slightly raise carvedilol exposure. Venlafaxine can also raise blood pressure, which may partly counter the effect of carvedilol.
How serious is the interaction between Carvedilol and Venlafaxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when venlafaxine is started or the dose changed, and adjust the carvedilol dose according to response.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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