Drug interactions
Carvedilol + Yohimbe
Severity: Moderate
Carvedilol and Yohimbe: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbe is an alpha-2 antagonist that increases sympathetic outflow, raising blood pressure and heart rate. This may oppose the antihypertensive effect of carvedilol, and yohimbe's cardiovascular toxicity may be a concern in patients with hypertension.
What this interaction means in plain words
Carvedilol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism: alpha-2 blockade increases noradrenaline release, opposing carvedilol's adrenergic blockade.
What to do
Advise avoiding yohimbe in patients with hypertension or heart failure on carvedilol. Monitor blood pressure and heart rate if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Yohimbe?
MediHelp rates the interaction as moderate. Carvedilol and Yohimbe can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbe is an alpha-2 antagonist that increases sympathetic outflow, raising blood pressure and heart rate. This may oppose the antihypertensive effect of carvedilol, and yohimbe's cardiovascular toxicity may be a concern in patients with hypertension.
How serious is the interaction between Carvedilol and Yohimbe?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding yohimbe in patients with hypertension or heart failure on carvedilol. Monitor blood pressure and heart rate if used.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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