Drug interactions
Cefalexin + Cyclopenthiazide
Severity: Minor
Cefalexin and Cyclopenthiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are cleared partly by renal tubular anion secretion, so cefalexin could marginally raise thiazide levels. This is a theoretical effect with minimal expected clinical impact.
What this interaction means in plain words
Cefalexin and Cyclopenthiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular anion secretion; clinical relevance is unproven.
What to do
No dose adjustment is required. Continue routine monitoring of blood pressure and electrolytes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefalexin
- Amikacin + Cefalexin Moderate
- Avelumab + Cefalexin Moderate
- Balstilimab + Cefalexin Moderate
- Bcg vaccine live + Cefalexin Moderate
- Cefalexin + Cholera vaccine Moderate
- Cefalexin + Kanamycin Moderate
Frequently asked questions
Can I take Cefalexin with Cyclopenthiazide?
MediHelp rates the interaction as minor. Cefalexin and Cyclopenthiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are cleared partly by renal tubular anion secretion, so cefalexin could marginally raise thiazide levels. This is a theoretical effect with minimal expected clinical impact.
How serious is the interaction between Cefalexin and Cyclopenthiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Continue routine monitoring of blood pressure and electrolytes.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
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