Drug interactions
Cefalexin + Ketorolac intranasal
Severity: Minor
Cefalexin and Ketorolac intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac is an organic acid cleared by the kidney and could compete with cefalexin for tubular secretion. With intranasal dosing the systemic exposure is limited and the effect is expected to be minor.
What this interaction means in plain words
Cefalexin and Ketorolac intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular anion secretion; clinical relevance is unproven.
What to do
No adjustment is needed. Monitor renal function if the patient has kidney disease or is dehydrated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefalexin
- Amikacin + Cefalexin Moderate
- Avelumab + Cefalexin Moderate
- Balstilimab + Cefalexin Moderate
- Bcg vaccine live + Cefalexin Moderate
- Cefalexin + Cholera vaccine Moderate
- Cefalexin + Kanamycin Moderate
Frequently asked questions
Can I take Cefalexin with Ketorolac intranasal?
MediHelp rates the interaction as minor. Cefalexin and Ketorolac intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketorolac is an organic acid cleared by the kidney and could compete with cefalexin for tubular secretion. With intranasal dosing the systemic exposure is limited and the effect is expected to be minor.
How serious is the interaction between Cefalexin and Ketorolac intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Monitor renal function if the patient has kidney disease or is dehydrated.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
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