Drug interactions
Cefalexin + Meclofenamate
Severity: Minor
Cefalexin and Meclofenamate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are acidic compounds secreted by renal tubular transporters, so cefalexin may marginally increase meclofenamate exposure. Any effect is expected to be small.
What this interaction means in plain words
Cefalexin and Meclofenamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular anion secretion between acidic drugs.
What to do
No change is required. Monitor for NSAID adverse effects as usual, particularly in renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefalexin
- Amikacin + Cefalexin Moderate
- Avelumab + Cefalexin Moderate
- Balstilimab + Cefalexin Moderate
- Bcg vaccine live + Cefalexin Moderate
- Cefalexin + Cholera vaccine Moderate
- Cefalexin + Kanamycin Moderate
Frequently asked questions
Can I take Cefalexin with Meclofenamate?
MediHelp rates the interaction as minor. Cefalexin and Meclofenamate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are acidic compounds secreted by renal tubular transporters, so cefalexin may marginally increase meclofenamate exposure. Any effect is expected to be small.
How serious is the interaction between Cefalexin and Meclofenamate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change is required. Monitor for NSAID adverse effects as usual, particularly in renal impairment.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
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