Drug interactions
Cefalexin + Parecoxib
Severity: Minor
Cefalexin and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is converted to valdecoxib, an acidic compound partly cleared by the kidney, so competition with cefalexin for tubular secretion is conceivable. Meaningful changes in exposure have not been shown.
What this interaction means in plain words
Cefalexin and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular anion secretion; clinical relevance is unproven.
What to do
No adjustment is needed. Monitor renal function in at-risk patients receiving NSAIDs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefalexin
- Amikacin + Cefalexin Moderate
- Avelumab + Cefalexin Moderate
- Balstilimab + Cefalexin Moderate
- Bcg vaccine live + Cefalexin Moderate
- Cefalexin + Cholera vaccine Moderate
- Cefalexin + Kanamycin Moderate
Frequently asked questions
Can I take Cefalexin with Parecoxib?
MediHelp rates the interaction as minor. Cefalexin and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Parecoxib is converted to valdecoxib, an acidic compound partly cleared by the kidney, so competition with cefalexin for tubular secretion is conceivable. Meaningful changes in exposure have not been shown.
How serious is the interaction between Cefalexin and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Monitor renal function in at-risk patients receiving NSAIDs.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
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