Drug interactions
Cefamandole + Fenoprofen
Severity: Minor
Cefamandole and Fenoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are organic anions eliminated partly by renal tubular secretion, so competition could slightly raise fenoprofen levels. The clinical effect is expected to be small. Cefamandole can also impair clotting, adding a minor bleeding consideration.
What this interaction means in plain words
Cefamandole and Fenoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal organic anion transporter secretion.
What to do
No routine adjustment is needed. Monitor for NSAID adverse effects and bleeding if used long term.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Cefamandole with Fenoprofen?
MediHelp rates the interaction as minor. Cefamandole and Fenoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are organic anions eliminated partly by renal tubular secretion, so competition could slightly raise fenoprofen levels. The clinical effect is expected to be small. Cefamandole can also impair clotting, adding a minor bleeding consideration.
How serious is the interaction between Cefamandole and Fenoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for NSAID adverse effects and bleeding if used long term.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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