Drug interactions
Cefepime / enmetazobactam + Ethinyl estradiol-levonorgestrel
Severity: Minor
Cefepime / enmetazobactam and Ethinyl estradiol-levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
It has been proposed that antibiotics could reduce enterohepatic recirculation of ethinyl estradiol through effects on gut flora. Pharmacokinetic studies have not shown consistent clinically significant reductions, and contraceptive failure is rare. This is an intravenous antibiotic used in a hospital setting.
What this interaction means in plain words
Cefepime / enmetazobactam and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of gut bacterial deconjugation of estrogen conjugates, lowering enterohepatic recirculation.
What to do
No routine change is needed. Advise the patient to follow missed pill rules if vomiting or severe diarrhea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Major
- Amobarbital + Ethinyl estradiol-levonorgestrel Major
- Anastrozole + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Cefepime / enmetazobactam with Ethinyl estradiol-levonorgestrel?
MediHelp rates the interaction as minor. Cefepime / enmetazobactam and Ethinyl estradiol-levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. It has been proposed that antibiotics could reduce enterohepatic recirculation of ethinyl estradiol through effects on gut flora. Pharmacokinetic studies have not shown consistent clinically significant reductions, and contraceptive failure is rare. This is an intravenous antibiotic used in a hospital setting.
How serious is the interaction between Cefepime / enmetazobactam and Ethinyl estradiol-levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise the patient to follow missed pill rules if vomiting or severe diarrhea occurs.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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