Drug interactions
Cefepime / enmetazobactam + Ethinyl estradiol-norgestimate
Severity: Minor
Cefepime / enmetazobactam and Ethinyl estradiol-norgestimate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibacterials have been theorised to reduce oral contraceptive efficacy by disrupting gut flora involved in estrogen recirculation. Evidence of true contraceptive failure with beta-lactams is lacking.
What this interaction means in plain words
Cefepime / enmetazobactam and Ethinyl estradiol-norgestimate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of enterohepatic recycling of ethinyl estradiol through altered gut flora; not well substantiated.
What to do
No routine change is required. Counsel on missed pills, and on vomiting or diarrhea, which may warrant backup contraception.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Frequently asked questions
Can I take Cefepime / enmetazobactam with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as minor. Cefepime / enmetazobactam and Ethinyl estradiol-norgestimate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibacterials have been theorised to reduce oral contraceptive efficacy by disrupting gut flora involved in estrogen recirculation. Evidence of true contraceptive failure with beta-lactams is lacking.
How serious is the interaction between Cefepime / enmetazobactam and Ethinyl estradiol-norgestimate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required. Counsel on missed pills, and on vomiting or diarrhea, which may warrant backup contraception.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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