Drug interactions
Ceftobiprole medocaril + Glibenclamide
Severity: Moderate
Ceftobiprole medocaril and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1 and OATP1B3, which contribute to hepatic uptake of glyburide. Raised glyburide exposure may increase the risk of hypoglycemia.
What this interaction means in plain words
Ceftobiprole medocaril and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake transport reduces glyburide clearance.
What to do
Monitor blood glucose during ceftobiprole therapy and counsel the patient on hypoglycemia symptoms. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Ceftobiprole medocaril with Glibenclamide?
MediHelp rates the interaction as moderate. Ceftobiprole medocaril and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftobiprole inhibits OATP1B1 and OATP1B3, which contribute to hepatic uptake of glyburide. Raised glyburide exposure may increase the risk of hypoglycemia.
How serious is the interaction between Ceftobiprole medocaril and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during ceftobiprole therapy and counsel the patient on hypoglycemia symptoms. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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