Drug interactions
Ceftobiprole medocaril + Methotrexate
Severity: Moderate
Ceftobiprole medocaril and Methotrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1 and OATP1B3 transporters and may raise concentrations of substrates such as methotrexate. Higher methotrexate exposure could increase myelosuppression, mucositis and organ toxicity.
What this interaction means in plain words
Ceftobiprole medocaril and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake reduces methotrexate clearance.
What to do
Monitor for methotrexate toxicity with blood counts, renal and liver tests, and measure methotrexate levels if high doses are used. Consider another antibiotic during high-dose methotrexate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methotrexate
- Acitretin + Methotrexate Contraindicated
- Adenovirus types 4 and 7 live + Methotrexate Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Methotrexate Contraindicated
- Ketorolac + Methotrexate Contraindicated
- Measles mumps and rubella vaccine live + Methotrexate Contraindicated
- Measles mumps and rubella vaccine + Methotrexate Contraindicated
Frequently asked questions
Can I take Ceftobiprole medocaril with Methotrexate?
MediHelp rates the interaction as moderate. Ceftobiprole medocaril and Methotrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftobiprole inhibits OATP1B1 and OATP1B3 transporters and may raise concentrations of substrates such as methotrexate. Higher methotrexate exposure could increase myelosuppression, mucositis and organ toxicity.
How serious is the interaction between Ceftobiprole medocaril and Methotrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for methotrexate toxicity with blood counts, renal and liver tests, and measure methotrexate levels if high doses are used. Consider another antibiotic during high-dose methotrexate.
What other medicines interact with Methotrexate?
MediHelp also lists interactions of Methotrexate with, for example, Acitretin, Adenovirus types 4 and 7 live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Methotrexate page.
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