Drug interactions
Ceftobiprole medocaril + Olmesartan
Severity: Moderate
Ceftobiprole medocaril and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1/1B3 and may increase exposure to olmesartan, which is an OATP1B1/1B3 substrate. The effect is likely modest and mainly leads to more hypotension or renal effects.
What this interaction means in plain words
Ceftobiprole medocaril and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake of olmesartan by ceftobiprole.
What to do
Monitor blood pressure and renal function during ceftobiprole therapy. Reduce the olmesartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Ceftobiprole medocaril with Olmesartan?
MediHelp rates the interaction as moderate. Ceftobiprole medocaril and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftobiprole inhibits OATP1B1/1B3 and may increase exposure to olmesartan, which is an OATP1B1/1B3 substrate. The effect is likely modest and mainly leads to more hypotension or renal effects.
How serious is the interaction between Ceftobiprole medocaril and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during ceftobiprole therapy. Reduce the olmesartan dose if hypotension occurs.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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