Drug interactions
Ceftobiprole medocaril + Pitavastatin
Severity: Moderate
Ceftobiprole medocaril and Pitavastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits OATP1B1 and OATP1B3 in vitro, and pitavastatin depends on these transporters for hepatic uptake. Exposure of pitavastatin may increase during treatment, raising the potential for muscle toxicity.
What this interaction means in plain words
Ceftobiprole medocaril and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake reduces pitavastatin hepatic clearance.
What to do
Consider holding pitavastatin during the short antibiotic course, or monitor for muscle symptoms and check CK if they appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pitavastatin
Frequently asked questions
Can I take Ceftobiprole medocaril with Pitavastatin?
MediHelp rates the interaction as moderate. Ceftobiprole medocaril and Pitavastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftobiprole inhibits OATP1B1 and OATP1B3 in vitro, and pitavastatin depends on these transporters for hepatic uptake. Exposure of pitavastatin may increase during treatment, raising the potential for muscle toxicity.
How serious is the interaction between Ceftobiprole medocaril and Pitavastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding pitavastatin during the short antibiotic course, or monitor for muscle symptoms and check CK if they appear.
What other medicines interact with Pitavastatin?
MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporin, Erythromycin base, Erythromycin ethylsuccinate. The full list is on the Pitavastatin page.
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