Drug interactions
Celiprolol + Clonidine
Severity: Moderate
Celiprolol and Clonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta blockers can intensify rebound hypertension after clonidine is stopped suddenly. Combined therapy may also cause additive bradycardia and hypotension.
What this interaction means in plain words
Celiprolol and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta blockade leaves alpha-mediated vasoconstriction unopposed during clonidine withdrawal; additive sympathetic suppression.
What to do
If stopping both, withdraw celiprolol first and then taper clonidine gradually. Monitor blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Frequently asked questions
Can I take Celiprolol with Clonidine?
MediHelp rates the interaction as moderate. Celiprolol and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta blockers can intensify rebound hypertension after clonidine is stopped suddenly. Combined therapy may also cause additive bradycardia and hypotension.
How serious is the interaction between Celiprolol and Clonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If stopping both, withdraw celiprolol first and then taper clonidine gradually. Monitor blood pressure and heart rate.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
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