Drug interactions
Celiprolol + Ketamine
Severity: Moderate
Celiprolol and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine normally raises heart rate and blood pressure through sympathetic stimulation, whereas celiprolol is a beta-blocker with vasodilating properties. The beta-blocker may blunt the sympathomimetic effect and, in catecholamine-depleted patients, ketamine's direct myocardial depressant effect may produce hypotension or bradycardia.
What this interaction means in plain words
Celiprolol and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition of ketamine's sympathetic stimulation by beta-blockade, with possible additive hypotension.
What to do
Monitor blood pressure and heart rate during and after ketamine administration, and have vasopressors and fluids available. Titrate ketamine dose to effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Celiprolol with Ketamine?
MediHelp rates the interaction as moderate. Celiprolol and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine normally raises heart rate and blood pressure through sympathetic stimulation, whereas celiprolol is a beta-blocker with vasodilating properties. The beta-blocker may blunt the sympathomimetic effect and, in catecholamine-depleted patients, ketamine's direct myocardial depressant effect may produce hypotension or bradycardia.
How serious is the interaction between Celiprolol and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate during and after ketamine administration, and have vasopressors and fluids available. Titrate ketamine dose to effect.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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