Drug interactions
Celiprolol + Ketorolac
Severity: Moderate
Celiprolol and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of beta-blockers, particularly with prolonged use. Ketorolac may also impair renal function in susceptible patients.
What this interaction means in plain words
Celiprolol and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of prostaglandin synthesis by ketorolac causes sodium and water retention and reduces vasodilatory prostaglandins, antagonizing the antihypertensive effect.
What to do
Monitor blood pressure when ketorolac is used for more than a few days with celiprolol. Adjust antihypertensive therapy if control is lost, or use a non-NSAID analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Frequently asked questions
Can I take Celiprolol with Ketorolac?
MediHelp rates the interaction as moderate. Celiprolol and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of beta-blockers, particularly with prolonged use. Ketorolac may also impair renal function in susceptible patients.
How serious is the interaction between Celiprolol and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ketorolac is used for more than a few days with celiprolol. Adjust antihypertensive therapy if control is lost, or use a non-NSAID analgesic.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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