Drug interactions
Celiprolol + Pirbuterol
Severity: Moderate
Celiprolol and Pirbuterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celiprolol is a beta-blocker with beta-1 selectivity and some beta-2 partial agonist activity, which can oppose the bronchodilator effect of pirbuterol. This may reduce asthma or COPD control, although the effect of a cardioselective agent is generally smaller than with nonselective drugs.
What this interaction means in plain words
Celiprolol and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors.
What to do
Monitor respiratory symptoms and lung function in patients with airway disease and consider a non-beta-blocker alternative if control worsens. Rescue beta-agonist doses may need to be increased.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Celiprolol with Pirbuterol?
MediHelp rates the interaction as moderate. Celiprolol and Pirbuterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celiprolol is a beta-blocker with beta-1 selectivity and some beta-2 partial agonist activity, which can oppose the bronchodilator effect of pirbuterol. This may reduce asthma or COPD control, although the effect of a cardioselective agent is generally smaller than with nonselective drugs.
How serious is the interaction between Celiprolol and Pirbuterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory symptoms and lung function in patients with airway disease and consider a non-beta-blocker alternative if control worsens. Rescue beta-agonist doses may need to be increased.
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