Drug interactions
Celiprolol + Prazosin
Severity: Moderate
Celiprolol and Prazosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so together they can cause excessive hypotension or postural dizziness, particularly when prazosin is first started. Celiprolol has some beta-2 agonist activity and vasodilating properties that add to the antihypertensive effect.
What this interaction means in plain words
Celiprolol and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antihypertensive effect from alpha-1 blockade and beta-1 blockade with vasodilation.
What to do
Introduce prazosin at a low first dose and titrate slowly. Monitor supine and standing blood pressure after starting or changing doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Celiprolol with Prazosin?
MediHelp rates the interaction as moderate. Celiprolol and Prazosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so together they can cause excessive hypotension or postural dizziness, particularly when prazosin is first started. Celiprolol has some beta-2 agonist activity and vasodilating properties that add to the antihypertensive effect.
How serious is the interaction between Celiprolol and Prazosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Introduce prazosin at a low first dose and titrate slowly. Monitor supine and standing blood pressure after starting or changing doses.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
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