Drug interactions
Cenobamate + Dextroamphetamine
Severity: Minor
Cenobamate and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and other enzymes, which may lower exposure to some co-administered drugs. Dextroamphetamine is mainly cleared by CYP2D6 and renal excretion, so a clinically meaningful effect is unlikely.
What this interaction means in plain words
Cenobamate and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cenobamate belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Cenobamate enzyme induction, though CYP3A4 is a minor route for amphetamine.
What to do
No routine adjustment is needed. Monitor clinical response to dextroamphetamine and adjust dose if effect appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Dextroamphetamine?
MediHelp rates the interaction as minor. Cenobamate and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cenobamate induces CYP3A4 and other enzymes, which may lower exposure to some co-administered drugs. Dextroamphetamine is mainly cleared by CYP2D6 and renal excretion, so a clinically meaningful effect is unlikely.
How serious is the interaction between Cenobamate and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor clinical response to dextroamphetamine and adjust dose if effect appears reduced.
What other medicines interact with Dextroamphetamine?
MediHelp also lists interactions of Dextroamphetamine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Dextroamphetamine page.
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