Drug interactions
Cenobamate + Esketamine
Severity: Moderate
Cenobamate and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate commonly causes somnolence, dizziness and fatigue, which may add to esketamine sedation and dissociation. Impaired alertness may be more pronounced.
What this interaction means in plain words
Cenobamate and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and impaired coordination during and after esketamine administration. Counsel patients not to drive until the following day after a restful sleep.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Esketamine?
MediHelp rates the interaction as moderate. Cenobamate and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate commonly causes somnolence, dizziness and fatigue, which may add to esketamine sedation and dissociation. Impaired alertness may be more pronounced.
How serious is the interaction between Cenobamate and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and impaired coordination during and after esketamine administration. Counsel patients not to drive until the following day after a restful sleep.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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