Drug interactions
Cenobamate + Etoposide
Severity: Moderate
Cenobamate and Etoposide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4 and may reduce etoposide concentrations, risking reduced antitumor efficacy.
What this interaction means in plain words
Cenobamate and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Etoposide belongs to Oncology.
Why it happens
Cenobamate induces CYP3A4, increasing the clearance of etoposide.
What to do
Monitor tumor response and consider a higher etoposide dose or an alternative antiseizure drug if efficacy appears reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contraindicated
- Etoposide + Pentostatin Contraindicated
- Cyclosporin + Etoposide Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Major
- Etoposide + Fingolimod Major
- Etoposide + Fosphenytoin Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Etoposide?
MediHelp rates the interaction as moderate. Cenobamate and Etoposide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4 and may reduce etoposide concentrations, risking reduced antitumor efficacy.
How serious is the interaction between Cenobamate and Etoposide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor tumor response and consider a higher etoposide dose or an alternative antiseizure drug if efficacy appears reduced.
What other medicines interact with Etoposide?
MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporin. The full list is on the Etoposide page.
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