Drug interactions
Cenobamate + Lamotrigine
Severity: Moderate
Cenobamate and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate can lower lamotrigine plasma concentrations, which may reduce seizure control. Cenobamate also causes somnolence and dizziness, so doses need careful titration.
What this interaction means in plain words
Cenobamate and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Lamotrigine belongs to Central Nervous System.
Why it happens
Cenobamate probably induces UDP-glucuronosyltransferase-mediated metabolism of lamotrigine, increasing its clearance.
What to do
Monitor seizure frequency and lamotrigine levels when cenobamate is started, changed or stopped. Increase the lamotrigine dose as needed, and reduce it again if cenobamate is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Lamotrigine?
MediHelp rates the interaction as moderate. Cenobamate and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate can lower lamotrigine plasma concentrations, which may reduce seizure control. Cenobamate also causes somnolence and dizziness, so doses need careful titration.
How serious is the interaction between Cenobamate and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and lamotrigine levels when cenobamate is started, changed or stopped. Increase the lamotrigine dose as needed, and reduce it again if cenobamate is withdrawn.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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