Drug interactions
Cenobamate + Lansoprazole
Severity: Minor
Cenobamate and Lansoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate inhibits CYP2C19 and induces CYP3A4, which have opposing effects on lansoprazole exposure. The net effect is unpredictable, so lansoprazole efficacy or tolerability may change.
What this interaction means in plain words
Cenobamate and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cenobamate belongs to Central Nervous System; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Cenobamate inhibits CYP2C19 and induces CYP3A4, both involved in lansoprazole metabolism.
What to do
Monitor symptom control of the acid-related condition and adjust the lansoprazole dose if response is inadequate or adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cenobamate and Lansoprazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Lansoprazole?
MediHelp rates the interaction as minor. Cenobamate and Lansoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cenobamate inhibits CYP2C19 and induces CYP3A4, which have opposing effects on lansoprazole exposure. The net effect is unpredictable, so lansoprazole efficacy or tolerability may change.
How serious is the interaction between Cenobamate and Lansoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control of the acid-related condition and adjust the lansoprazole dose if response is inadequate or adverse effects emerge.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
