Drug interactions
Cenobamate + Pimozide
Severity: Moderate
Cenobamate and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP3A4, which may lower pimozide concentrations and reduce its effectiveness. Cenobamate also causes somnolence, which adds to pimozide sedation. Its effect on QT is shortening, so QT risk is not increased.
What this interaction means in plain words
Cenobamate and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Cenobamate induction of CYP3A4 increases pimozide clearance, with additive CNS depression.
What to do
Monitor for reduced pimozide effect and increase the dose cautiously if needed, with ECG monitoring. Reassess the dose if cenobamate is stopped, since pimozide levels may rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cenobamate and Pimozide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Pimozide?
MediHelp rates the interaction as moderate. Cenobamate and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP3A4, which may lower pimozide concentrations and reduce its effectiveness. Cenobamate also causes somnolence, which adds to pimozide sedation. Its effect on QT is shortening, so QT risk is not increased.
How serious is the interaction between Cenobamate and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced pimozide effect and increase the dose cautiously if needed, with ECG monitoring. Reassess the dose if cenobamate is stopped, since pimozide levels may rise.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
