Drug interactions
Cenobamate + Tofacitinib
Severity: Moderate
Cenobamate and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate inhibits CYP2C19 but also induces CYP3A4, which is the main route of tofacitinib clearance. The net effect is uncertain and could be reduced tofacitinib exposure.
What this interaction means in plain words
Cenobamate and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Tofacitinib belongs to Musculoskeletal.
Why it happens
Cenobamate inhibits CYP2C19 and induces CYP3A4, giving opposing effects on tofacitinib metabolism.
What to do
Monitor clinical response and adverse effects when cenobamate is started or stopped. Adjust the tofacitinib dose according to response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Tofacitinib?
MediHelp rates the interaction as moderate. Cenobamate and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate inhibits CYP2C19 but also induces CYP3A4, which is the main route of tofacitinib clearance. The net effect is uncertain and could be reduced tofacitinib exposure.
How serious is the interaction between Cenobamate and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and adverse effects when cenobamate is started or stopped. Adjust the tofacitinib dose according to response and tolerability.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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