Drug interactions
Cenobamate + Zaleplon
Severity: Moderate
Cenobamate and Zaleplon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate commonly causes somnolence, dizziness and fatigue, which may add to zaleplon's sedative effect. This can impair alertness and coordination.
What this interaction means in plain words
Cenobamate and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Zaleplon belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Use the lowest effective zaleplon dose and monitor for excessive sedation. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Zaleplon?
MediHelp rates the interaction as moderate. Cenobamate and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate commonly causes somnolence, dizziness and fatigue, which may add to zaleplon's sedative effect. This can impair alertness and coordination.
How serious is the interaction between Cenobamate and Zaleplon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective zaleplon dose and monitor for excessive sedation. Advise against driving until the response is known.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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