Drug interactions
Cenobamate + Zolpidem
Severity: Moderate
Cenobamate and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate commonly causes somnolence, dizziness and fatigue, and zolpidem can add to these effects. Impaired coordination and next-day drowsiness may be more pronounced.
What this interaction means in plain words
Cenobamate and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cenobamate belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS depression; cenobamate also induces CYP3A4, which may modestly lower zolpidem exposure.
What to do
Monitor for sedation and impaired psychomotor function, and warn patients about driving. Adjust zolpidem dose according to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Cenobamate
Frequently asked questions
Can I take Cenobamate with Zolpidem?
MediHelp rates the interaction as moderate. Cenobamate and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate commonly causes somnolence, dizziness and fatigue, and zolpidem can add to these effects. Impaired coordination and next-day drowsiness may be more pronounced.
How serious is the interaction between Cenobamate and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and impaired psychomotor function, and warn patients about driving. Adjust zolpidem dose according to response.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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