Drug interactions
Cephalexin + Metformin-sitagliptin
Severity: Moderate
Cephalexin and Metformin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalexin can raise metformin concentrations by reducing its renal tubular secretion. This may increase the risk of metformin accumulation and lactic acidosis, especially with renal impairment.
What this interaction means in plain words
Cephalexin and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion via MATE1/OCT2 transporters reduces metformin clearance.
What to do
Monitor renal function and blood glucose during cephalexin therapy, and consider metformin dose reduction in patients with reduced renal function or other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Cephalexin with Metformin-sitagliptin?
MediHelp rates the interaction as moderate. Cephalexin and Metformin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalexin can raise metformin concentrations by reducing its renal tubular secretion. This may increase the risk of metformin accumulation and lactic acidosis, especially with renal impairment.
How serious is the interaction between Cephalexin and Metformin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood glucose during cephalexin therapy, and consider metformin dose reduction in patients with reduced renal function or other risk factors.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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