Drug interactions
Cephaloridine + Dexamethasone-tobramycin
Severity: Moderate
Cephaloridine and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephaloridine is itself markedly nephrotoxic and is no longer in clinical use. Combined with an aminoglycoside it would increase kidney injury risk, but exposure to ophthalmic tobramycin is minimal.
What this interaction means in plain words
Cephaloridine and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive proximal tubular toxicity.
What to do
Avoid combining with systemic aminoglycosides; if encountered, monitor renal function closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Frequently asked questions
Can I take Cephaloridine with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Cephaloridine and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephaloridine is itself markedly nephrotoxic and is no longer in clinical use. Combined with an aminoglycoside it would increase kidney injury risk, but exposure to ophthalmic tobramycin is minimal.
How serious is the interaction between Cephaloridine and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with systemic aminoglycosides; if encountered, monitor renal function closely.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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