Drug interactions
Chlordiazepoxide + Clonidine
Severity: Moderate
Chlordiazepoxide and Clonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clonidine and benzodiazepines both cause sedation, and clonidine also lowers blood pressure. Together they can cause excessive drowsiness, psychomotor impairment and hypotension.
What this interaction means in plain words
Chlordiazepoxide and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Clonidine belongs to Cardiovascular.
Why it happens
Additive CNS depression via central alpha-2 agonism and GABA-A potentiation.
What to do
Use the lowest effective benzodiazepine dose and monitor sedation and blood pressure, especially in older adults. Avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlordiazepoxide and Clonidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Clonidine
- Acebutolol + Clonidine Major
- Amifostine + Clonidine Major
- Amiodarone + Clonidine Major
- Amoxapine + Clonidine Major
- Atenolol-chlorthalidone + Clonidine Major
- Atenolol + Clonidine Major
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Clonidine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Clonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clonidine and benzodiazepines both cause sedation, and clonidine also lowers blood pressure. Together they can cause excessive drowsiness, psychomotor impairment and hypotension.
How serious is the interaction between Chlordiazepoxide and Clonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective benzodiazepine dose and monitor sedation and blood pressure, especially in older adults. Avoid alcohol and other sedatives.
What other medicines interact with Clonidine?
MediHelp also lists interactions of Clonidine with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Clonidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
