Drug interactions
Chlordiazepoxide + Conivaptan
Severity: Moderate
Chlordiazepoxide and Conivaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Conivaptan is a CYP3A4 inhibitor and may increase chlordiazepoxide exposure. Higher levels can prolong sedation and psychomotor impairment, particularly in older or hepatically impaired patients.
What this interaction means in plain words
Chlordiazepoxide and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Conivaptan inhibits CYP3A4, reducing the metabolism of chlordiazepoxide and its active metabolites.
What to do
Monitor for excessive sedation during the short conivaptan course and reduce the chlordiazepoxide dose if needed. Consider a benzodiazepine not metabolized by CYP3A4, such as lorazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Conivaptan?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Conivaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Conivaptan is a CYP3A4 inhibitor and may increase chlordiazepoxide exposure. Higher levels can prolong sedation and psychomotor impairment, particularly in older or hepatically impaired patients.
How serious is the interaction between Chlordiazepoxide and Conivaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation during the short conivaptan course and reduce the chlordiazepoxide dose if needed. Consider a benzodiazepine not metabolized by CYP3A4, such as lorazepam.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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