Drug interactions
Chlordiazepoxide + Dabrafenib
Severity: Moderate
Chlordiazepoxide and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower chlordiazepoxide exposure, potentially reducing efficacy. Loss of symptom control or withdrawal suppression may occur.
What this interaction means in plain words
Chlordiazepoxide and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Dabrafenib belongs to Oncology.
Why it happens
Induction of CYP3A4 by dabrafenib increases benzodiazepine clearance.
What to do
Monitor clinical response and increase the chlordiazepoxide dose if needed, or use lorazepam, which is not CYP3A4 dependent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Dabrafenib
Frequently asked questions
Can I take Chlordiazepoxide with Dabrafenib?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower chlordiazepoxide exposure, potentially reducing efficacy. Loss of symptom control or withdrawal suppression may occur.
How serious is the interaction between Chlordiazepoxide and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the chlordiazepoxide dose if needed, or use lorazepam, which is not CYP3A4 dependent.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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