Drug interactions
Chlordiazepoxide + Danazol
Severity: Moderate
Chlordiazepoxide and Danazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak to moderate CYP3A4 inhibitor and can slow the oxidative metabolism of chlordiazepoxide. This may lead to higher concentrations and more prolonged sedation and psychomotor impairment, particularly in older patients.
What this interaction means in plain words
Chlordiazepoxide and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Danazol inhibits CYP3A4, reducing hepatic and intestinal clearance of chlordiazepoxide.
What to do
Monitor for oversedation and confusion, and reduce the chlordiazepoxide dose if signs of excess effect appear. Consider a benzodiazepine cleared by glucuronidation if the combination is needed long term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Danazol?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Danazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danazol is a weak to moderate CYP3A4 inhibitor and can slow the oxidative metabolism of chlordiazepoxide. This may lead to higher concentrations and more prolonged sedation and psychomotor impairment, particularly in older patients.
How serious is the interaction between Chlordiazepoxide and Danazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and confusion, and reduce the chlordiazepoxide dose if signs of excess effect appear. Consider a benzodiazepine cleared by glucuronidation if the combination is needed long term.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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