Drug interactions
Chlordiazepoxide + Dextroamphetamine
Severity: Minor
Chlordiazepoxide and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stimulants can mask the sedation from benzodiazepines without reversing impairment of judgment or psychomotor performance. The opposing effects make the clinical outcome unpredictable and patients may feel more alert than they are.
What this interaction means in plain words
Chlordiazepoxide and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlordiazepoxide belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Opposing CNS effects; amphetamine increases catecholamine release while benzodiazepines enhance GABA-A inhibition, with no established pharmacokinetic interaction.
What to do
No dose change is generally needed. Advise patients not to rely on feeling alert when driving and reassess the need for each drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Dextroamphetamine?
MediHelp rates the interaction as minor. Chlordiazepoxide and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stimulants can mask the sedation from benzodiazepines without reversing impairment of judgment or psychomotor performance. The opposing effects make the clinical outcome unpredictable and patients may feel more alert than they are.
How serious is the interaction between Chlordiazepoxide and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Advise patients not to rely on feeling alert when driving and reassess the need for each drug.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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