Drug interactions
Chlordiazepoxide + Dextromoramide
Severity: Major
Chlordiazepoxide and Dextromoramide: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a benzodiazepine with a potent opioid such as dextromoramide can cause profound sedation, respiratory depression, coma and death. Regulators have issued warnings on opioid-benzodiazepine co-prescription.
What this interaction means in plain words
Chlordiazepoxide and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid receptor agonism and GABA-A potentiation.
What to do
Avoid combining when possible; if essential, use the lowest effective doses for the shortest duration and monitor respiratory rate and sedation closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Dextromoramide?
MediHelp rates the interaction as major. Chlordiazepoxide and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a benzodiazepine with a potent opioid such as dextromoramide can cause profound sedation, respiratory depression, coma and death. Regulators have issued warnings on opioid-benzodiazepine co-prescription.
How serious is the interaction between Chlordiazepoxide and Dextromoramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining when possible; if essential, use the lowest effective doses for the shortest duration and monitor respiratory rate and sedation closely.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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