Drug interactions
Chlordiazepoxide + Disulfiram
Severity: Moderate
Chlordiazepoxide and Disulfiram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram can slow the oxidative metabolism of chlordiazepoxide, raising its levels and prolonging sedation. The effect is generally modest but may matter in patients with alcohol dependence, where both drugs are commonly used.
What this interaction means in plain words
Chlordiazepoxide and Disulfiram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Disulfiram inhibits hepatic oxidative metabolism of chlordiazepoxide.
What to do
Monitor for excessive sedation and psychomotor impairment, and reduce the chlordiazepoxide dose if needed. Lorazepam or oxazepam are alternatives not dependent on oxidation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Disulfiram?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Disulfiram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disulfiram can slow the oxidative metabolism of chlordiazepoxide, raising its levels and prolonging sedation. The effect is generally modest but may matter in patients with alcohol dependence, where both drugs are commonly used.
How serious is the interaction between Chlordiazepoxide and Disulfiram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and psychomotor impairment, and reduce the chlordiazepoxide dose if needed. Lorazepam or oxazepam are alternatives not dependent on oxidation.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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