Drug interactions
Chlordiazepoxide + Droperidol
Severity: Moderate
Chlordiazepoxide and Droperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Droperidol is a sedating neuroleptic, and with chlordiazepoxide it can cause additive sedation and hypotension. Droperidol also carries QT prolongation risk, but the benzodiazepine does not add to it.
What this interaction means in plain words
Chlordiazepoxide and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from dopamine and histamine blockade plus GABA-A potentiation.
What to do
Reduce doses of one or both agents and monitor sedation level, blood pressure and respiration, particularly after parenteral droperidol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Droperidol?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Droperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Droperidol is a sedating neuroleptic, and with chlordiazepoxide it can cause additive sedation and hypotension. Droperidol also carries QT prolongation risk, but the benzodiazepine does not add to it.
How serious is the interaction between Chlordiazepoxide and Droperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce doses of one or both agents and monitor sedation level, blood pressure and respiration, particularly after parenteral droperidol.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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