Drug interactions
Chlordiazepoxide + Fexinidazole
Severity: Moderate
Chlordiazepoxide and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may inhibit CYP3A4 and could raise chlordiazepoxide levels. This may increase sedation and psychomotor impairment.
What this interaction means in plain words
Chlordiazepoxide and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole and its metabolites inhibit CYP3A4, reducing chlordiazepoxide clearance.
What to do
Monitor for excess sedation and reduce the chlordiazepoxide dose if needed. Consider lorazepam if a benzodiazepine is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Fexinidazole?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may inhibit CYP3A4 and could raise chlordiazepoxide levels. This may increase sedation and psychomotor impairment.
How serious is the interaction between Chlordiazepoxide and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and reduce the chlordiazepoxide dose if needed. Consider lorazepam if a benzodiazepine is required.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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