Drug interactions
Chlordiazepoxide + Ketamine
Severity: Moderate
Chlordiazepoxide and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzodiazepines are often given with ketamine to reduce emergence reactions, but together they increase sedation and may cause respiratory depression. Recovery may be prolonged and hypotension can occur.
What this interaction means in plain words
Chlordiazepoxide and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and NMDA receptor antagonism.
What to do
Titrate doses to effect and monitor oxygenation, respiratory rate and blood pressure. Ensure airway support is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Other interactions of Ketamine
Frequently asked questions
Can I take Chlordiazepoxide with Ketamine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzodiazepines are often given with ketamine to reduce emergence reactions, but together they increase sedation and may cause respiratory depression. Recovery may be prolonged and hypotension can occur.
How serious is the interaction between Chlordiazepoxide and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate doses to effect and monitor oxygenation, respiratory rate and blood pressure. Ensure airway support is available.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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