Drug interactions
Chlordiazepoxide + Lofepramine
Severity: Moderate
Chlordiazepoxide and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine, a tricyclic antidepressant, has sedative properties that add to those of chlordiazepoxide. Psychomotor impairment and drowsiness may be increased.
What this interaction means in plain words
Chlordiazepoxide and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from antihistaminic and other sedative actions combined with benzodiazepine GABAergic effects.
What to do
Monitor for drowsiness and impaired coordination, and use the lowest effective doses. Warn patients about driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Lofepramine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine, a tricyclic antidepressant, has sedative properties that add to those of chlordiazepoxide. Psychomotor impairment and drowsiness may be increased.
How serious is the interaction between Chlordiazepoxide and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and impaired coordination, and use the lowest effective doses. Warn patients about driving and alcohol.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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