Drug interactions
Chlordiazepoxide + Lormetazepam
Severity: Major
Chlordiazepoxide and Lormetazepam: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two benzodiazepines produces additive sedation, residual daytime impairment and a risk of respiratory depression. Falls and confusion are a particular concern in older patients.
What this interaction means in plain words
Chlordiazepoxide and Lormetazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive GABA-A receptor mediated CNS depression.
What to do
Avoid combined use and use only one benzodiazepine at the lowest effective dose. Monitor sedation and breathing if overlap cannot be avoided.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Lormetazepam?
MediHelp rates the interaction as major. Chlordiazepoxide and Lormetazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two benzodiazepines produces additive sedation, residual daytime impairment and a risk of respiratory depression. Falls and confusion are a particular concern in older patients.
How serious is the interaction between Chlordiazepoxide and Lormetazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use and use only one benzodiazepine at the lowest effective dose. Monitor sedation and breathing if overlap cannot be avoided.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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