Drug interactions
Chlordiazepoxide + Marijuana
Severity: Moderate
Chlordiazepoxide and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis produces drowsiness and impaired cognition and coordination, which add to benzodiazepine effects. Combined use may increase accidents and impair judgment.
What this interaction means in plain words
Chlordiazepoxide and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through cannabinoid receptor and GABAergic effects.
What to do
Advise patients to avoid cannabis while on chlordiazepoxide and not to drive or operate machinery. Monitor for excessive sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Marijuana?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis produces drowsiness and impaired cognition and coordination, which add to benzodiazepine effects. Combined use may increase accidents and impair judgment.
How serious is the interaction between Chlordiazepoxide and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid cannabis while on chlordiazepoxide and not to drive or operate machinery. Monitor for excessive sedation.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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