Drug interactions
Chlordiazepoxide + Metoclopramide intranasal
Severity: Moderate
Chlordiazepoxide and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause sedation, drowsiness and extrapyramidal effects, and benzodiazepines may add to CNS depression. Intranasal systemic exposure is lower, but additive somnolence is plausible.
What this interaction means in plain words
Chlordiazepoxide and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; metoclopramide's central dopamine antagonism contributes to sedation.
What to do
Monitor for excess drowsiness and counsel against driving. Reduce the benzodiazepine dose if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause sedation, drowsiness and extrapyramidal effects, and benzodiazepines may add to CNS depression. Intranasal systemic exposure is lower, but additive somnolence is plausible.
How serious is the interaction between Chlordiazepoxide and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness and counsel against driving. Reduce the benzodiazepine dose if sedation is troublesome.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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