Drug interactions
Chlordiazepoxide + Miconazole vaginal
Severity: Minor
Chlordiazepoxide and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vaginal miconazole has some systemic absorption and can inhibit CYP3A4, but exposure is low, so a meaningful rise in chlordiazepoxide is unlikely in most patients.
What this interaction means in plain words
Chlordiazepoxide and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP3A4 inhibition by absorbed miconazole.
What to do
No routine adjustment is needed. Monitor for excess sedation if used repeatedly or in a frail patient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Miconazole vaginal?
MediHelp rates the interaction as minor. Chlordiazepoxide and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vaginal miconazole has some systemic absorption and can inhibit CYP3A4, but exposure is low, so a meaningful rise in chlordiazepoxide is unlikely in most patients.
How serious is the interaction between Chlordiazepoxide and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for excess sedation if used repeatedly or in a frail patient.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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