Drug interactions
Chlordiazepoxide + Midazolam intranasal
Severity: Major
Chlordiazepoxide and Midazolam intranasal: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Two benzodiazepines used together produce additive sedation and may cause hypoventilation, airway obstruction or apnea. Effects can be profound and prolonged.
What this interaction means in plain words
Chlordiazepoxide and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive GABA-A receptor-mediated central nervous system and respiratory depression.
What to do
Avoid unnecessary co-use and reduce the midazolam dose when chlordiazepoxide has been taken. Monitor respiration and sedation, with resuscitation capability available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Midazolam intranasal?
MediHelp rates the interaction as major. Chlordiazepoxide and Midazolam intranasal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Two benzodiazepines used together produce additive sedation and may cause hypoventilation, airway obstruction or apnea. Effects can be profound and prolonged.
How serious is the interaction between Chlordiazepoxide and Midazolam intranasal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary co-use and reduce the midazolam dose when chlordiazepoxide has been taken. Monitor respiration and sedation, with resuscitation capability available.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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