Drug interactions
Chlordiazepoxide + Moxonidine
Severity: Moderate
Chlordiazepoxide and Moxonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine can cause drowsiness and sedation, and benzodiazepines may enhance this effect. Labeling notes that moxonidine may increase the sedative effect of benzodiazepines.
What this interaction means in plain words
Chlordiazepoxide and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from central alpha-2/imidazoline agonism and benzodiazepine action.
What to do
Monitor for sedation and dizziness, and counsel on driving. Reduce the chlordiazepoxide dose if drowsiness is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Moxonidine?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine can cause drowsiness and sedation, and benzodiazepines may enhance this effect. Labeling notes that moxonidine may increase the sedative effect of benzodiazepines.
How serious is the interaction between Chlordiazepoxide and Moxonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and dizziness, and counsel on driving. Reduce the chlordiazepoxide dose if drowsiness is excessive.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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