Drug interactions
Chlordiazepoxide + Nafcillin
Severity: Minor
Chlordiazepoxide and Nafcillin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nafcillin is a CYP3A4 inducer and may lower concentrations of CYP3A4-metabolized drugs such as chlordiazepoxide. The effect is likely modest, and reduced anxiolytic or anticonvulsant effect is possible.
What this interaction means in plain words
Chlordiazepoxide and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Nafcillin-mediated CYP3A4 induction increases chlordiazepoxide clearance.
What to do
Monitor clinical response during and after nafcillin therapy and adjust the chlordiazepoxide dose if effect is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Nafcillin?
MediHelp rates the interaction as minor. Chlordiazepoxide and Nafcillin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nafcillin is a CYP3A4 inducer and may lower concentrations of CYP3A4-metabolized drugs such as chlordiazepoxide. The effect is likely modest, and reduced anxiolytic or anticonvulsant effect is possible.
How serious is the interaction between Chlordiazepoxide and Nafcillin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response during and after nafcillin therapy and adjust the chlordiazepoxide dose if effect is reduced.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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