Drug interactions
Chlordiazepoxide + Nefazodone
Severity: Moderate
Chlordiazepoxide and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone strongly inhibits CYP3A4 and also is sedating. Chlordiazepoxide exposure may increase, intensifying sedation and psychomotor impairment.
What this interaction means in plain words
Chlordiazepoxide and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone inhibits CYP3A4, reducing chlordiazepoxide metabolism, with additive sedative effects.
What to do
Monitor for oversedation and consider reducing the chlordiazepoxide dose. Use lorazepam or oxazepam if a benzodiazepine is required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Nefazodone?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone strongly inhibits CYP3A4 and also is sedating. Chlordiazepoxide exposure may increase, intensifying sedation and psychomotor impairment.
How serious is the interaction between Chlordiazepoxide and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and consider reducing the chlordiazepoxide dose. Use lorazepam or oxazepam if a benzodiazepine is required.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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