Drug interactions
Chlordiazepoxide + Olanzapine / samidorphan
Severity: Moderate
Chlordiazepoxide and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine causes sedation and orthostatic hypotension, and combining it with a benzodiazepine increases these effects. Parenteral olanzapine with benzodiazepines has been associated with cardiorespiratory depression.
What this interaction means in plain words
Chlordiazepoxide and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotensive effects of olanzapine and the benzodiazepine.
What to do
Monitor sedation and blood pressure, especially on standing, and counsel on falls. Reduce doses if excessive drowsiness or dizziness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlordiazepoxide
Frequently asked questions
Can I take Chlordiazepoxide with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine causes sedation and orthostatic hypotension, and combining it with a benzodiazepine increases these effects. Parenteral olanzapine with benzodiazepines has been associated with cardiorespiratory depression.
How serious is the interaction between Chlordiazepoxide and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, especially on standing, and counsel on falls. Reduce doses if excessive drowsiness or dizziness develops.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
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