Drug interactions
Chlordiazepoxide + Pimozide
Severity: Moderate
Chlordiazepoxide and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, so combined use increases sedation and motor impairment. Pimozide additionally carries QT-prolongation risk, so any condition raising its exposure or causing electrolyte disturbance is of concern.
What this interaction means in plain words
Chlordiazepoxide and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlordiazepoxide belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A potentiation and antipsychotic receptor blockade.
What to do
Monitor sedation and counsel on driving and alcohol. Keep pimozide on its usual ECG and electrolyte monitoring schedule.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlordiazepoxide and Pimozide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlordiazepoxide
Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Frequently asked questions
Can I take Chlordiazepoxide with Pimozide?
MediHelp rates the interaction as moderate. Chlordiazepoxide and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, so combined use increases sedation and motor impairment. Pimozide additionally carries QT-prolongation risk, so any condition raising its exposure or causing electrolyte disturbance is of concern.
How serious is the interaction between Chlordiazepoxide and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and counsel on driving and alcohol. Keep pimozide on its usual ECG and electrolyte monitoring schedule.
What other medicines interact with Chlordiazepoxide?
MediHelp also lists interactions of Chlordiazepoxide with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
